Wnt3a

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{{#invoke:Infobox_gene|getTemplateData}} Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc[3] and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.[2]

Significance

Wnt signaling pathway has been demonstrated to drive hindgut identity during gastrointestinal development, and the up regulation of the Wnt3a in pluripotent stem cell has been used to direct their differentiation for the generation of intestinal Organoids and tissues in vitro[4][5][6].

References

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  2. 2.0 2.1 {{#invoke:citation/CS1|citation |CitationClass=web }}
  3. http://www.jbc.org/content/280/25/24004.full
  4. PMID 3033971 (PubMed)
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  5. Zhang, X., Chen, Y., Ye, Y., Wang, J., Wang, H., Yuan, G., . . . Lin, X. (2017). Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation. Cellular Signalling, 29, 12-22. doi:10.1016/j.cellsig.2016.09.009
  6. Lancaster, M. A., & Knoblich, J. A. (2014). Organogenesis in a dish: Modeling development and disease using organoid technologies. Science, 345(6194), 1247125-1247125. doi:10.1126/science.1247125

Further reading

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